The Metro Milers annually put on this premiere 10K race.  The best in the Midwest, this event is tailored to be enjoyed by all who participate as runners, walkers, and volunteers. A portion of the race budget is dedicated every year to benefit not for profit organizations.

The Route 66 10K is hosted by the Metro Milers running club as part of  the City of Edwardsville IL's Route 66 Festival.  The race attracts individuals from the St. Louis metro and beyond.